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Design of 5′ Untranslated Sequences in Retroviral Vectors Developed for Medical Use

Utilizing genetic modules of simple retroviruses, we have developed a novel generation of gene transfer vectors with improved therapeutic potential. In the 5′ untranslated “leader” sequences, all AUG codons which may aberrantly initiate translation and all viral coding sequences were removed. Thus,...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Hildinger, Markus, Abel, Kristin L., Ostertag, Wolfram, Baum, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104187/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10196304/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.5.4083-4089.1999
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