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Design of 5′ Untranslated Sequences in Retroviral Vectors Developed for Medical Use

Utilizing genetic modules of simple retroviruses, we have developed a novel generation of gene transfer vectors with improved therapeutic potential. In the 5′ untranslated “leader” sequences, all AUG codons which may aberrantly initiate translation and all viral coding sequences were removed. Thus,...

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Библиографические подробности
Опубликовано в::J Virol
Главные авторы: Hildinger, Markus, Abel, Kristin L., Ostertag, Wolfram, Baum, Christopher
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 1999
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104187/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10196304/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.5.4083-4089.1999
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