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Design of 5′ Untranslated Sequences in Retroviral Vectors Developed for Medical Use

Utilizing genetic modules of simple retroviruses, we have developed a novel generation of gene transfer vectors with improved therapeutic potential. In the 5′ untranslated “leader” sequences, all AUG codons which may aberrantly initiate translation and all viral coding sequences were removed. Thus,...

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Autori principali: Hildinger, Markus, Abel, Kristin L., Ostertag, Wolfram, Baum, Christopher
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC104187/
https://ncbi.nlm.nih.gov/pubmed/10196304
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