Irreversible Inhibition of Human Immunodeficiency Virus Type 1 Integrase by Dicaffeoylquinic Acids

Human immunodeficiency virus type 1 (HIV-1) and other retroviruses require integration of a double-stranded DNA copy of the RNA genome into the host cell chromosome for productive infection. The viral enzyme, integrase, catalyzes the integration of retroviral DNA and represents an attractive target...

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Bibliographic Details
Main Authors: Zhu, Kai, Cordeiro, Mara L., Atienza, Jocelyn, Robinson, W. Edward, Chow, Samson A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC104095/
https://ncbi.nlm.nih.gov/pubmed/10074185
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