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Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation

Several studies have shown improved efficacy of cholesteryl-conjugated phosphorothioate antisense oligodeoxynucleotides. To gain insight into the mechanisms of the improved efficacy in vivo, we investigated the disposition of ISIS-9388, the 3′-cholesterol analog of the ICAM-1-specific phosphoro­thio...

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Udgivet i:Nucleic Acids Res
Principais autores: Bijsterbosch, Martin K., Rump, Erik T., Vrueh, Remco L. A. De, Dorland, Rick, Veghel, Richard van, Tivel, Kathleen L., Biessen, Erik A. L., Berkel, Theo J. C. van, Manoharan, Muthiah
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102653/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908328/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.14.2717
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