Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation

Several studies have shown improved efficacy of cholesteryl-conjugated phosphorothioate antisense oligodeoxynucleotides. To gain insight into the mechanisms of the improved efficacy in vivo, we investigated the disposition of ISIS-9388, the 3′-cholesterol analog of the ICAM-1-specific phosphoro­thio...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Bijsterbosch, Martin K., Rump, Erik T., Vrueh, Remco L. A. De, Dorland, Rick, Veghel, Richard van, Tivel, Kathleen L., Biessen, Erik A. L., Berkel, Theo J. C. van, Manoharan, Muthiah
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2000
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC102653/
https://ncbi.nlm.nih.gov/pubmed/10908328
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars