Evernimicin (SCH27899) Inhibits a Novel Ribosome Target Site: Analysis of 23S Ribosomal DNA Mutants

Spontaneous mutants of susceptible clinical and laboratory isolates of Streptococcus pneumoniae exhibiting reduced susceptibility to evernimicin (SCH27899; MIC, 0.5 to 4.0 mg/liter) were selected on plates containing evernimicin. Four isolates that did not harbor mutations in rplP (which encodes rib...

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Detalhes bibliográficos
Main Authors: Adrian, Peter V., Mendrick, Cara, Loebenberg, David, McNicholas, Paul, Shaw, Karen J., Klugman, Keith P., Hare, Roberta S., Black, Todd A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC101610/
https://ncbi.nlm.nih.gov/pubmed/11036030
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