Evernimicin (SCH27899) Inhibits a Novel Ribosome Target Site: Analysis of 23S Ribosomal DNA Mutants

Spontaneous mutants of susceptible clinical and laboratory isolates of Streptococcus pneumoniae exhibiting reduced susceptibility to evernimicin (SCH27899; MIC, 0.5 to 4.0 mg/liter) were selected on plates containing evernimicin. Four isolates that did not harbor mutations in rplP (which encodes rib...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Adrian, Peter V., Mendrick, Cara, Loebenberg, David, McNicholas, Paul, Shaw, Karen J., Klugman, Keith P., Hare, Roberta S., Black, Todd A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Mechanisms of Action: Physiological Effects
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101610/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11036030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.11.3101-3106.2000
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