Expression and Characterization of Recombinant Human-Derived Pneumocystis carinii Dihydrofolate Reductase

Dihydrofolate reductase (DHFR) is the target of trimethoprim (TMP), which has been widely used in combination with sulfa drugs for treatment and prophylaxis of Pneumocystis carinii pneumonia. While the rat-derived P. carinii DHFR has been well characterized, kinetic studies of human-derived P. carin...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Ma, Liang, Kovacs, Joseph A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101608/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11036028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.11.3092-3096.2000
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