Expression and Characterization of Recombinant Human-Derived Pneumocystis carinii Dihydrofolate Reductase
Dihydrofolate reductase (DHFR) is the target of trimethoprim (TMP), which has been widely used in combination with sulfa drugs for treatment and prophylaxis of Pneumocystis carinii pneumonia. While the rat-derived P. carinii DHFR has been well characterized, kinetic studies of human-derived P. carin...
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| Publicat a: | Antimicrob Agents Chemother |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101608/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11036028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.11.3092-3096.2000 |
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