Expression and Characterization of Recombinant Human-Derived Pneumocystis carinii Dihydrofolate Reductase

Dihydrofolate reductase (DHFR) is the target of trimethoprim (TMP), which has been widely used in combination with sulfa drugs for treatment and prophylaxis of Pneumocystis carinii pneumonia. While the rat-derived P. carinii DHFR has been well characterized, kinetic studies of human-derived P. carin...

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Podrobná bibliografie

Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Ma, Liang, Kovacs, Joseph A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2000
Témata:	Mechanisms of Resistance
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101608/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11036028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.11.3092-3096.2000
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