Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein

Transient intracellular expression of ExoT in CHO cells stimulated cell rounding and actin reorganization. Biochemical studies showed that ExoT was a GTPase-activating protein for RhoA, Rac1, and Cdc42. Together, these data show that ExoT interferes with Rho signal transduction pathways, which regul...

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Main Authors: Krall, Rebecca, Schmidt, Gudula, Aktories, Klaus, Barbieri, Joseph T.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Molecular and Cellular Pathogenesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC101576/
https://ncbi.nlm.nih.gov/pubmed/10992524
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