The contribution of 2′-hydroxyls to the cleavage activity of the Neurospora VS ribozyme

We have used nucleotide analog interference mapping and site-specific substitution to determine the effect of 2′-deoxynucleotide substitution of each nucleotide in the VS ribozyme on the self-cleavage reaction. A large number of 2′-hydroxyls (2′-OHs) that contribute to cleavage activity of the VS ri...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Sood, Vanita D., Yekta, Soraya, Collins, Richard A.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 2002
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101248/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11861903/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.5.1132
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