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The contribution of 2′-hydroxyls to the cleavage activity of the Neurospora VS ribozyme

We have used nucleotide analog interference mapping and site-specific substitution to determine the effect of 2′-deoxynucleotide substitution of each nucleotide in the VS ribozyme on the self-cleavage reaction. A large number of 2′-hydroxyls (2′-OHs) that contribute to cleavage activity of the VS ri...

Cur síos iomlán

Sábháilte in:
Sonraí bibleagrafaíochta
Foilsithe in:Nucleic Acids Res
Príomhchruthaitheoirí: Sood, Vanita D., Yekta, Soraya, Collins, Richard A.
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Oxford University Press 2002
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101248/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11861903/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.5.1132
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