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Protein Binding Protects Sites on Stable Episomes and in the Chromosome from De Novo Methylation
We have utilized the Escherichia coli lac repressor-operator system to test whether protein binding can interfere with de novo DNA methylation in mammalian cells. We find that a DNA binding protein can protect sites on the episome as well as in the genome from the de novo methylation activity of Dnm...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC100263/ https://ncbi.nlm.nih.gov/pubmed/11313467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3416-3424.2001 |
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