Protein Binding Protects Sites on Stable Episomes and in the Chromosome from De Novo Methylation

We have utilized the Escherichia coli lac repressor-operator system to test whether protein binding can interfere with de novo DNA methylation in mammalian cells. We find that a DNA binding protein can protect sites on the episome as well as in the genome from the de novo methylation activity of Dnm...

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Bibliographic Details
Main Authors: Han, Li, Lin, Iping G., Hsieh, Chih-Lin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC100263/
https://ncbi.nlm.nih.gov/pubmed/11313467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3416-3424.2001
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