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Effect of SpeB and EndoS from Streptococcus pyogenes on Human Immunoglobulins

Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has...

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Bibliografski detalji
Izdano u:Infect Immun
Glavni autori: Collin, Mattias, Olsén, Arne
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2001
Teme:
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC100124/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11598100/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.11.7187-7189.2001
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