Effect of SpeB and EndoS from Streptococcus pyogenes on Human Immunoglobulins

Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has...

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Bibliographic Details
Main Authors: Collin, Mattias, Olsén, Arne
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC100124/
https://ncbi.nlm.nih.gov/pubmed/11598100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.11.7187-7189.2001
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