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Systemic Akt1 Deletion after Tumor Onset in p53−/− Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration

Akt is frequently activated in human cancers. However, it is unknown whether systemic inhibition of a single Akt isoform could regress cancer progression in cancers that are not driven by Akt activation. We systemically deleted Akt1 after tumor onset in p53−/− mice, which develop tumors independentl...

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Bibliografiske detaljer
Main Authors: Wan-Ni Yu, Veronique Nogueira, Arya Sobhakumari, Krushna C. Patra, Prashanth T. Bhaskar, Nissim Hay
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015-07-01
Serier:Cell Reports
Online adgang:http://www.sciencedirect.com/science/article/pii/S221112471500683X
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