Reconfigured metabolism brain network in asymptomatic microtubule-associated protein tau mutation carriers: a graph theoretical analysis

Abstract Background Studies exploring topological properties of the metabolic network during the presymptomatic stage of genetic frontotemporal dementia (FTD) are scarce. However, such knowledge is important for understanding brain function and disease pathogenesis. Therefore, we aimed to explore FT...

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Hauptverfasser: Li Liu, Min Chu, Binbin Nie, Lin Liu, Kexin Xie, Yue Cui, Yu Kong, Zhongyun Chen, Haitian Nan, Kewei Chen, Pedro Rosa-Neto, Liyong Wu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2022-04-01
Schriftenreihe:Alzheimer’s Research & Therapy
Schlagworte:
Frontotemporal dementia
MAPT gene
FDG-PET
Brain network
Graph theory
Online Zugang:https://doi.org/10.1186/s13195-022-01000-z
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