Impact of Natural Compounds on DNA Methylation Levels of the Tumor Suppressor Gene RASSF1A in Cancer

Epigenetic inactivation of tumor suppressor genes (TSG) is a fundamental event in the pathogenesis of human cancer. This silencing is accomplished by aberrant chromatin modifications including DNA hypermethylation of the gene promoter. One of the most frequently hypermethylated TSG in human cancer i...

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Main Authors: Reinhard H. Dammann, Antje M. Richter, Adriana P. Jiménez, Michelle Woods, Miriam Küster, Chamindri Witharana
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2017-10-01
Serier:International Journal of Molecular Sciences
Fag:
DNA methylation
tumor suppressor gene
RASSF1
demethylation
natural compounds
Online adgang:https://www.mdpi.com/1422-0067/18/10/2160
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