Impact of Natural Compounds on DNA Methylation Levels of the Tumor Suppressor Gene RASSF1A in Cancer

Epigenetic inactivation of tumor suppressor genes (TSG) is a fundamental event in the pathogenesis of human cancer. This silencing is accomplished by aberrant chromatin modifications including DNA hypermethylation of the gene promoter. One of the most frequently hypermethylated TSG in human cancer i...

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Главные авторы: Reinhard H. Dammann, Antje M. Richter, Adriana P. Jiménez, Michelle Woods, Miriam Küster, Chamindri Witharana
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2017-10-01
Серии:International Journal of Molecular Sciences
Предметы:
DNA methylation
tumor suppressor gene
RASSF1
demethylation
natural compounds
Online-ссылка:https://www.mdpi.com/1422-0067/18/10/2160
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