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Bones in human CYP26B1 deficiency and rats with hypervitaminosis A phenocopy Vegfa overexpression

Angulated femurs are present prenatally both in CYP26B1 deficient humans with a reduced capacity to degrade retinoic acid (RA, the active metabolite of vitamin A), and mice overexpressing vascular endothelial growth factor a (Vegfa). Since excessive ingestion of vitamin A is known to induce spontane...

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Hlavní autoři: Thomas Lind, Roberta Lugano, Ann-Marie Gustafson, Maria Norgård, Arie van Haeringen, Anna Dimberg, Håkan Melhus, Stephen P. Robertson, Göran Andersson
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2018-12-01
Edice:Bone Reports
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2352187218300391
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