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Excessive dietary intake of vitamin A reduces skull bone thickness in mice

Calvarial thinning and skull bone defects have been reported in infants with hypervitaminosis A. These findings have also been described in humans, mice and zebrafish with loss-of-function mutations in the enzyme CYP26B1 that degrades retinoic acid (RA), the active metabolite of vitamin A, indicatin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lind, Thomas, Öhman, Caroline, Calounova, Gabriela, Rasmusson, Annica, Andersson, Göran, Pejler, Gunnar, Melhus, Håkan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398668/
https://ncbi.nlm.nih.gov/pubmed/28426756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176217
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