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Excessive dietary intake of vitamin A reduces skull bone thickness in mice

Calvarial thinning and skull bone defects have been reported in infants with hypervitaminosis A. These findings have also been described in humans, mice and zebrafish with loss-of-function mutations in the enzyme CYP26B1 that degrades retinoic acid (RA), the active metabolite of vitamin A, indicatin...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Lind, Thomas, Öhman, Caroline, Calounova, Gabriela, Rasmusson, Annica, Andersson, Göran, Pejler, Gunnar, Melhus, Håkan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398668/
https://ncbi.nlm.nih.gov/pubmed/28426756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176217
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