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Bidirectional Crosstalk between C5a Receptors and the NLRP3 Inflammasome in Macrophages and Monocytes

C5a is an inflammatory mediator generated by complement activation that positively regulates various arms of immune defense, including Toll-like receptor 4 (TLR4) signaling. The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome is activated by pathogen products and cellular/ti...

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Main Authors: Mikel D. Haggadone, Jamison J. Grailer, Fatemeh Fattahi, Firas S. Zetoune, Peter A. Ward
格式: Artigo
語言:Inglês
出版: Hindawi Limited 2016-01-01
叢編:Mediators of Inflammation
在線閱讀:http://dx.doi.org/10.1155/2016/1340156
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