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Critical role for C5aRs in the development of septic lymphopenia in mice()

In the early stages of sepsis, lymphocytes undergo apoptosis, resulting in lymphopenia and immunosuppression. The trigger for septic lymphopenia is unknown. Using the polymicrobial model of murine sepsis, we investigated the role of C5a receptors in septic lymphopenia. In wild type mice, CLP resulte...

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Detalles Bibliográficos
Publicado en:J Immunol
Main Authors: Grailer, Jamison J., Fattahi, Fatemeh, Dick, Rachel S., Zetoune, Firas S., Ward, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297720/
https://ncbi.nlm.nih.gov/pubmed/25539817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401193
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