<i>N</i>-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells

The main mechanistic function of most chemotherapeutic drugs is mediated by inducing mitochondria-dependent apoptosis. Tumor cells usually respond to upregulate autophagy to eliminate impaired mitochondria for survival. Hypothetically, inhibiting autophagy might promote mitochondria-dependent apopto...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kun Wang, Bonan Chen, Ting Yin, Yujuan Zhan, Yuhua Lu, Yilin Zhang, Jiawei Chen, Weijie Wu, Shikun Zhou, Wenli Mao, Yuhui Tan, Biaoyan Du, Xiaodong Liu, Hiuting Idy HO, Jianyong Xiao
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2019-07-01
Colección:International Journal of Molecular Sciences
Materias:
<i>N</i>-Methylparoxetine
NSCLC
autophagy inhibition
ROS
MAPK
apoptosis
Acceso en línea:https://www.mdpi.com/1422-0067/20/14/3415
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares