<i>N</i>-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells

The main mechanistic function of most chemotherapeutic drugs is mediated by inducing mitochondria-dependent apoptosis. Tumor cells usually respond to upregulate autophagy to eliminate impaired mitochondria for survival. Hypothetically, inhibiting autophagy might promote mitochondria-dependent apopto...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Kun Wang, Bonan Chen, Ting Yin, Yujuan Zhan, Yuhua Lu, Yilin Zhang, Jiawei Chen, Weijie Wu, Shikun Zhou, Wenli Mao, Yuhui Tan, Biaoyan Du, Xiaodong Liu, Hiuting Idy HO, Jianyong Xiao
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI AG 2019-07-01
Sraith:International Journal of Molecular Sciences
Ábhair:
<i>N</i>-Methylparoxetine
NSCLC
autophagy inhibition
ROS
MAPK
apoptosis
Rochtain Ar Líne:https://www.mdpi.com/1422-0067/20/14/3415
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla