Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells

Abstract Background Selectively utilizing alternative mechanisms to repair damaged DNA in essential factors deficient cancer facilitates tumor genetic evolution and contributes to treatment resistance. Synthetic lethality strategies provide a novel scenario to anticancer therapy with DNA repair prot...

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Hauptverfasser: Jing Zhang, Mu Chen, Ying Pang, Meng Cheng, Bingsong Huang, Siyi Xu, Min Liu, Hao Lian, Chunlong Zhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2022-04-01
Schriftenreihe:Journal of Experimental & Clinical Cancer Research
Schlagworte:
Glioma
DNA replication
Tumor genetic evolution
DNA damage
Genome instability
Synthetic lethality
Online Zugang:https://doi.org/10.1186/s13046-022-02334-0
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