Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells

Abstract Background Selectively utilizing alternative mechanisms to repair damaged DNA in essential factors deficient cancer facilitates tumor genetic evolution and contributes to treatment resistance. Synthetic lethality strategies provide a novel scenario to anticancer therapy with DNA repair prot...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Jing Zhang, Mu Chen, Ying Pang, Meng Cheng, Bingsong Huang, Siyi Xu, Min Liu, Hao Lian, Chunlong Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Glioma
DNA replication
Tumor genetic evolution
DNA damage
Genome instability
Synthetic lethality
Acesso em linha:https://doi.org/10.1186/s13046-022-02334-0
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados