FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis

Abstract Background In idiopathic pulmonary fibrosis (IPF), fibroblasts gain a more migratory phenotype and excessively secrete extracellular matrix (ECM), ultimately leading to alveolar scarring and progressive dyspnea. Here, we analyzed the effects of deficiency of FK506-binding protein 10 (FKBP10...

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Detalhes bibliográficos
Main Authors: Larissa Knüppel, Katharina Heinzelmann, Michael Lindner, Rudolf Hatz, Jürgen Behr, Oliver Eickelberg, Claudia A. Staab-Weijnitz
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-04-01
Colecção:Respiratory Research
Assuntos:
FKBP10
FKBP65
migration
focal adhesion
collagen VI
lung fibrosis
Acesso em linha:http://link.springer.com/article/10.1186/s12931-018-0768-1
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