BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221)

Spontaneous Ca2+ transients and actin dynamics in primary motoneurons correspond to cellular differentiation such as axon elongation and growth cone formation. Brain-derived neurotrophic factor (BDNF) and its receptor trkB support both motoneuron survival and synaptic differentiation. However, in mo...

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Bibliographische Detailangaben
Hauptverfasser: Benjamin Dombert, Stefanie Balk, Patrick Lüningschrör, Mehri Moradi, Rajeeve Sivadasan, Lena Saal-Bauernschubert, Sibylle Jablonka
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017-10-01
Schriftenreihe:Frontiers in Molecular Neuroscience
Schlagworte:
BDNF
trkB
Cav2.2
F-actin
motor axon
growth cone
Online Zugang:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00346/full
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