Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function

Protein inclusions containing the RNA-binding protein TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis and other neurodegenerative disorders. The loss of TDP-43 function that is associated with these inclusions affects post-transcriptional processing of RNAs in multiple ways inclu...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Briese, Michael, Saal-Bauernschubert, Lena, Lüningschrör, Patrick, Moradi, Mehri, Dombert, Benjamin, Surrey, Verena, Appenzeller, Silke, Deng, Chunchu, Jablonka, Sibylle, Sendtner, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7379803/
https://ncbi.nlm.nih.gov/pubmed/32709255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00987-6
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