An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs

Pigs share many similarities with humans in terms of anatomy, physiology and genetics, and have long been recognized as important experimental animals in biomedical research. Using an N-ethyl-N-nitrosourea (ENU) mutagenesis screen, we previously identified a large number of pig mutants, which could...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chunwei Cao, Ying Zhang, Qitao Jia, Xiao Wang, Qiantao Zheng, Hongyong Zhang, Ruigao Song, Yongshun Li, Ailing Luo, Qianlong Hong, Guosong Qin, Jing Yao, Nan Zhang, Yanfang Wang, Hongmei Wang, Qi Zhou, Jianguo Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2019-01-01
Colecção:Disease Models & Mechanisms
Assuntos:
Pigs
Animal model
ENU
Exome sequencing
Congenital hypothyroidism
Acesso em linha:http://dmm.biologists.org/content/12/1/dmm036616
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados