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Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs
Pigs are ideal organ donors for xenotransplantation and an excellent model for studying human diseases, such as neurodegenerative disease. Transcription activator-like effector nucleases (TALENs) are used widely for gene targeting in various model animals. Here, we developed a strategy using TALENs...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4220281/ https://ncbi.nlm.nih.gov/pubmed/25370805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06926 |
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