Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs

Pigs are ideal organ donors for xenotransplantation and an excellent model for studying human diseases, such as neurodegenerative disease. Transcription activator-like effector nucleases (TALENs) are used widely for gene targeting in various model animals. Here, we developed a strategy using TALENs...

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Pubblicato in:Sci Rep
Autori principali: Yao, Jing, Huang, Jiaojiao, Hai, Tang, Wang, Xianlong, Qin, Guosong, Zhang, Hongyong, Wu, Rong, Cao, Chunwei, Xi, Jianzhong Jeff, Yuan, Zengqiang, Zhao, Jianguo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220281/
https://ncbi.nlm.nih.gov/pubmed/25370805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06926
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