Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

Abstract Background Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB osteocyte network contributes t...

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Hlavní autoři: Katherine A. Staines, Ekele Ikpegbu, Anna E. Törnqvist, Scott Dillon, Behzad Javaheri, Anish K. Amin, Dylan N. Clements, David J. Buttle, Andrew A. Pitsillides, Colin Farquharson
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2019-07-01
Edice:BMC Musculoskeletal Disorders
Témata:
Osteocytes
Subchondral bone
Osteoarthritis
E11/podoplanin
On-line přístup:http://link.springer.com/article/10.1186/s12891-019-2731-9
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