Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

BACKGROUND: Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB osteocyte network contributes to the in...

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Pubblicato in:BMC Musculoskelet Disord
Autori principali: Staines, Katherine A., Ikpegbu, Ekele, Törnqvist, Anna E., Dillon, Scott, Javaheri, Behzad, Amin, Anish K., Clements, Dylan N., Buttle, David J., Pitsillides, Andrew A., Farquharson, Colin
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6661085/
https://ncbi.nlm.nih.gov/pubmed/31351471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-019-2731-9
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