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Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

Abstract Background Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB osteocyte network contributes t...

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Bibliographic Details
Main Authors: Katherine A. Staines, Ekele Ikpegbu, Anna E. Törnqvist, Scott Dillon, Behzad Javaheri, Anish K. Amin, Dylan N. Clements, David J. Buttle, Andrew A. Pitsillides, Colin Farquharson
Format: Artigo
Language:Inglês
Published: BMC 2019-07-01
Series:BMC Musculoskeletal Disorders
Subjects:
Osteocytes
Subchondral bone
Osteoarthritis
E11/podoplanin
Online Access:http://link.springer.com/article/10.1186/s12891-019-2731-9
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