Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival.

In the mammalian inner ear neurosensory cell fate depends on three closely related transcription factors, Atoh1 for hair cells and Neurog1 and Neurod1 for neurons. We have previously shown that neuronal cell fate can be altered towards hair cell fate by eliminating Neurod1 mediated repression of Ato...

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Hlavní autoři: Israt Jahan, Ning Pan, Jennifer Kersigo, Lilian E Calisto, Ken A Morris, Benjamin Kopecky, Jeremy S Duncan, Kirk W Beisel, Bernd Fritzsch
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2012-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC3265522?pdf=render
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