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A Novel Atoh1 “Self-Terminating” Mouse Model Reveals the Necessity of Proper Atoh1 Level and Duration for Hair Cell Differentiation and Viability

Atonal homolog1 (Atoh1) is a bHLH transcription factor essential for inner ear hair cell differentiation. Targeted expression of Atoh1 at various stages in development can result in hair cell differentiation in the ear. However, the level and duration of Atoh1 expression required for proper hair cel...

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Autors principals: Pan, Ning, Jahan, Israt, Kersigo, Jennifer, Duncan, Jeremy S., Kopecky, Benjamin, Fritzsch, Bernd
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261193/
https://ncbi.nlm.nih.gov/pubmed/22279587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030358
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