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The tail of cryptochromes: an intrinsically disordered cog within the mammalian circadian clock

Abstract Cryptochrome (CRY) proteins play an essential role in regulating mammalian circadian rhythms. CRY is composed of a structured N-terminal domain known as the photolyase homology region (PHR), which is tethered to an intrinsically disordered C-terminal tail. The PHR domain is a critical hub f...

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Detalhes bibliográficos
Main Authors: Gian Carlo G. Parico, Carrie L. Partch
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-11-01
Colecção:Cell Communication and Signaling
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Acesso em linha:http://link.springer.com/article/10.1186/s12964-020-00665-z
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