Factor H binds to the hypervariable region of many Streptococcus pyogenes M proteins but does not promote phagocytosis resistance or acute virulence.

Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as first described for Streptococcus pyogenes and the antiphagocytic M6 protein. It is commonly assumed that FH recruited to an M protein enhances virulence by protecting the bacteria against complement...

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Main Authors: Mattias C U Gustafsson, Jonas Lannergård, O Rickard Nilsson, Bodil M Kristensen, John E Olsen, Claire L Harris, Rafael L Ufret-Vincenty, Margaretha Stålhammar-Carlemalm, Gunnar Lindahl
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2013-01-01
Colecção:PLoS Pathogens
Acesso em linha:http://europepmc.org/articles/PMC3630203?pdf=render
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