Sequence variability is correlated with weak immunogenicity in Streptococcus pyogenes M protein

The M protein of Streptococcus pyogenes, a major bacterial virulence factor, has an amino-terminal hypervariable region (HVR) that is a target for type-specific protective antibodies. Intriguingly, the HVR elicits a weak antibody response, indicating that it escapes host immunity by two mechanisms,...

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Detalhes bibliográficos
Publicado no:Microbiologyopen
Main Authors: Lannergård, Jonas, Kristensen, Bodil M, Gustafsson, Mattias C U, Persson, Jenny J, Norrby-Teglund, Anna, Stålhammar-Carlemalm, Margaretha, Lindahl, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618610/
https://ncbi.nlm.nih.gov/pubmed/26175306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mbo3.278
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