Factor H Binds to the Hypervariable Region of Many Streptococcus pyogenes M Proteins but Does Not Promote Phagocytosis Resistance or Acute Virulence

Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as first described for Streptococcus pyogenes and the antiphagocytic M6 protein. It is commonly assumed that FH recruited to an M protein enhances virulence by protecting the bacteria against complement...

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Main Authors: Gustafsson, Mattias C. U., Lannergård, Jonas, Nilsson, O. Rickard, Kristensen, Bodil M., Olsen, John E., Harris, Claire L., Ufret-Vincenty, Rafael L., Stålhammar-Carlemalm, Margaretha, Lindahl, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630203/
https://ncbi.nlm.nih.gov/pubmed/23637608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003323
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