The HECT E3 ligase E6AP/UBE3A as a Therapeutic Target in Cancer and Neurological Disorders

The HECT (Homologous to the E6-AP Carboxyl Terminus)-family protein E6AP (E6-associated protein), encoded by the <i>UBE3A</i> gene, is a multifaceted ubiquitin ligase that controls diverse signaling pathways involved in cancer and neurological disorders. The oncogenic role of E6AP in pap...

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Main Authors: Asia Owais, Rama K. Mishra, Hiroaki Kiyokawa
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-07-01
Colecção:Cancers
Assuntos:
ubiquitin
viral oncogenesis
oncoproteins
tumor suppressors
Angelman syndrome
autism
Acesso em linha:https://www.mdpi.com/2072-6694/12/8/2108
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