Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation

ABSTRACT The generation of T cells with maximal anti-tumor activities will significantly impact the field of T-cell-based adoptive immunotherapy. In this report, we found that OKT3/IL-2-stimulated T cells were phenotypically more heterogeneous, with enhanced anti-tumor activity in vitro and when loc...

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Main Authors: Xiaojun Liu, Shuguang Jiang, Chongyun Fang, Hua Li, Xuhua Zhang, Fuqin Zhang, Carl H. June, Yangbing Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2017-05-01
Colecção:Protein & Cell
Assuntos:
T lymphocytes
CAR
manufacture
gene transfer
RNA electroporation
Acesso em linha:http://link.springer.com/article/10.1007/s13238-017-0422-6
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