Ploidy reductions in murine fusion-derived hepatocytes.

We previously showed that fusion between hepatocytes lacking a crucial liver enzyme, fumarylacetoacetate hydrolase (FAH), and wild-type blood cells resulted in hepatocyte reprogramming. FAH expression was restored in hybrid hepatocytes and, upon in vivo expansion, ameliorated the effects of FAH defi...

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Главные авторы: Andrew W Duncan, Raymond D Hickey, Nicole K Paulk, Andrew J Culberson, Susan B Olson, Milton J Finegold, Markus Grompe
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science (PLoS) 2009-02-01
Серии:PLoS Genetics
Online-ссылка:http://europepmc.org/articles/PMC2636893?pdf=render
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