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Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alphaM2-cap.

Gating of nicotinic acetylcholine receptors from a C(losed) to an O(pen) conformation is the initial event in the postsynaptic signaling cascade at the vertebrate nerve-muscle junction. Studies of receptor structure and function show that many residues in this large, five-subunit membrane protein co...

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Bibliografski detalji
Glavni autori: Pallavi A Bafna, Prasad G Purohit, Anthony Auerbach
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2008-06-01
Serija:PLoS ONE
Online pristup:http://europepmc.org/articles/PMC2429975?pdf=render
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