The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.

We recently published that the positive inotropic response (PIR) to levosimendan can be fully accounted for by phosphodiesterase (PDE) inhibition in both failing human heart and normal rat heart. To determine if the PIR of the active metabolite OR-1896, an important mediator of the long-term clinica...

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書誌詳細
主要な著者: Øivind Ørstavik, Ornella Manfra, Kjetil Wessel Andressen, Geir Øystein Andersen, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy, Kurt Allen Krobert
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science (PLoS) 2015-01-01
シリーズ:PLoS ONE
オンライン･アクセス:http://europepmc.org/articles/PMC4349697?pdf=render
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